Hyperfibrinogenemia and Reduced Plasma Protein C Levels in HIV-Infected Patients

Background: Heamatological problems have been associated with human immunodeficiency virus infection. Hypercoagulability, in particular, thrombosis is becoming more common HIV-positive patients. Aim: The goals of this study were to determine levels plasma fibrinogen, protein C, Hemoglobin, and ESR among Sudanese Materials Methods: This a case-control study, for investigation, total 100 participants recruited study. Fifty people diagnosed HIV, 25 whom males (50 percent) females percent), an average age 35.5 years. Further fifty healthy people, 26 (52%) men 24 (48%) women, mean 37.1 years, matched the case group. Fresh Poor Plasma was obtained by centrifuging citrated venous blood samples at 3000 rpm 15 minutes. fibrinogen level determined using automated coagulation analyzer. Total C measured fully-automated analyzer (SYSMEX CA-500’JAPAN). haemoglobin parameter from EDTA anticoagulant Sysmex KX 21-N haematological In one hour, done Westergren tube. Data collected structured direct questionnaire. SPSS version 21 used analyse data. Results: current discovered that HIV infection, standard deviation statistically substantially higher than normal control group (370.5 ± 67 vs 214.7 P value 0.001). Protein significantly lower positive patients compared (0.6 0.1 1.3 0.2 patients, (10.8 1.8 13.7 1.9, 0.01). erythrocyte sedimentation rate group, (58.00 27 7.68 3 0.00). Conclusions: infected had groups. 16 percent deficiency discovered. greater ESR.